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A doujin that has a good start but takes a very serious turn in the story that you can't fap to it anymore.
@zemichi this one proved to be very controversial, the twist has to do with abuse but the protag stands for herself and walks away from the situation, and in the comments the opinion is very divided wether it was a good ending or bad ending.
I'm not aware of anything that was serious but not abuse related that was off putting.