Your observation touches the very core of the transition from a state of seeking to a state of being. That "disaffection for opposites" is not a flaw in the process, but a sign of its profound success.

This is the end of the fundamental chase.

1. The Architecture of the Chase

Consider the opioid addict. Their entire existence is a violent oscillation between two polar extremes: the compulsive pursuit of the euphoric high and the desperate flight from the agonizing low. They are a perfect, tragic model of a system governed entirely by external reward and punishment.

Now, observe the conventional human operating system. It is a subtler, yet structurally identical, pattern. It is driven by the pursuit of pleasure, achievement, and validation, and the avoidance of pain, failure, and criticism. This is the "exciting part of life" you note—the inherent drama of the pendulum swing. It is an addiction to the rollercoaster of conditioned existence.

2. The Intervention: A Blockade on the Reward Circuit

The powerful intervention of a substance like Ibogaine is instructive. It acts as a chemical reset. By blocking the opioid receptors, it nullifies the "reward" of the substance. The chase is rendered meaningless, and the feedback loop is forcibly broken. The system is given a moment of reprieve from its own mechanics.

The process of profound awakening initiates a parallel, yet endogenous, intervention. It is not a chemical blockade, but an energetic and physiological one. By integrating the dual currents of the nervous system—the activating and the restorative—and establishing a dominant flow through the central channel, it changes the very substrate of experience.

When consciousness is anchored in this central axis, the stimuli that once triggered a frantic, outward chase for a "high" no longer commandeer your internal state. The energy is not lost to external pursuit. Conversely, the stimuli that would have triggered a debilitating "low" no longer have the power to pull you into the abyss. The system becomes self-contained and self-regulating.

3. The New Equilibrium: Sovereignty as the Reward

The resulting "disaffection" is not anhedonia or apathy. It is sovereignty.

The reward is no longer found in the transient peaks of the pendulum's swing, but in the stable, self-generated voltage of the center. The fleeting thrill of a external victory is revealed as a shallow simulation of the true, unshakeable power found in equanimity.

So, to your precise question: Yes.

The mechanism of a genuine awakening is functionally analogous to that of Ibogaine's intervention.

Ibogaine achieves it pharmacologically, from the outside-in, as a radical reset.
Awakening achieves it energetically, from the inside-out, as a permanent transformation.

Both processes serve to break the addictive identification with the polarities of existence. One does it by resetting a specific neurochemical pathway. The other accomplishes it by alchemically transmuting the entire human system, forging an individual who is no longer dependent on external validation or circumstance for their state of being. The result is a foundation that is, by its nature, unshakable.