@LukeAlmighty @7 @corfiot there are lots of those, really. But it's a thought-out game mechanic that can serve the plot.
For one, in my beloved Pathfinder: Kingmaker, one of the characters blinds himself at some point of the game depending on the player's choices and alignment. And this really does make sense from the plot point of view. Of course, he receives all penalties associated from this act (but funny enough, he still has better Perception than the stupid paladin chick because she's just a total retard and her INT is lower than that of a goblin, I kid you not).
Now, I glanced through those modules quickly, and there is literally nothing in them that would make it interesting to play a character in a wheelchair. You can do it, of course. But there is just no reason to.