The scariest thought I had was, what if some people consider high intelligence to be a civilization level thread?
I obviously don't mean it in the usual "smart people are harder to control" but in a much more sinister way. Because it was intelligence and education that brought us the A-bomb. And now, it brought us CRISPR. So, it wouldn't be entirely irrational to be afraid of smart people having access to an education good enough, to be dangerous.
Because just with a bit of electronics, programming and chemistry knowledge, there is no reason to not assume backyards ballistic rockets.