@meeper@shebang@xue I still have Qubes and Nix on my wishlist of distros to try. While Qubes would be great for work related stuff. Not sure what Nix would be good for.
Qubes is pretty good if you don't care about performance and you swear off vidya. Definitely useful if you have multiple identities you want to keep separate.
NixOS has a very powerful package manager (it even has something like use flags[1]) and some niceties like installing packages per-user or even per-shell, rolling back if anything breaks, and built-in support for wacky stuff like fido2luks or whatever. Main drawbacks is that there's no FHS so most binaries you download off the internet won't work without patching. Also the community seems a bit soy-devvy so I wonldn't rely on it for stability/security.
And nix seems cool, but I'm not that ready to delve into systemd