There are probably enough vtubers at this point that you could play "Who's that pokemon" but with vtubers.

>"Who's that pokemon?!"
>Is it Gura?
>"It's.... Mumei!"

Also Pokemon gen 1 romhack that replaces the pokemon with vtubers.

You get Gura, Kiara, or Fauna as starters.

Ina'nis would probably replace Ditto. It probably has the most tako vibe out of all the pokemon.