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The regenerators become basically irrelevant when you get the thermal scope (so, uh, you fight maybe one without it) but the atmosphere is just right and they still are fun to kill. Hopefully they'll have some surprises in the remake...
Although, I guess if it's your first time, you wouldn't really know how to deal with them. I kind of don't care to use the rifle anyway, so if I didn't know I needed it for the scope I wouldn't have had it.