@cjd Some sensitive equipment I've seen uses air pressure to prevent tempering, much like a jar of preserves.
Much like the jar's lid, a small capsule, connected to the electronics, lets air out without issues, as the assembly is sealed and vacuumed.
But if pressure is ever to increase, it bursts.
A couple of magnetic bits on a spring mechanism generate a current spike, overload and fry the electronics.
I'm sure it's more complicated than that, but this isn't my field, and I'm recalling things from years ago, but that's the general idea.
@cjd A worthy endeavor.
How about LIDAR, machine learning, or AI?
A camera inside the assembly that detects anything that differs from the expected state of things.
A tiny internal patrolman.
With the state of robotics these days, it shouldn't be too difficult.
I'm imagining how one would build an absolutely diabolical weapon - an "exploding shock collar" which has a voice modulator that demands crypto payment within some # of hours - and which cannot be removed, not be police, FBI, CIA, Mossad, ANY ONE.