@Jens_Rasmussen
He has a clear goal. He's a scientist, who want to create a "perfect race", so he does see death of others as nothing but another step in his process.
He even goes as far, as to cause a planet-sized extinction, since the civilization he created wasn't up to his standard.
The difference between him and other villains is, that in his case, you know exactly why he's a threat. And that makes him seriously menacing.